The community maintained a synagogue, several other religious institutions, a school that was operative until 1937 and a public library. A number of charitable, welfare and cultural organizations were active in the community, including an organization supporting the school, an organization for the development of social and cultural life in the community and a loan fund that also maintained activity until 1937. There were two hevrot kadisha (burial societies) – the first for the general public, the second for women only. The latter was also responsible for arranging the hospitalization of poor children and assistance for impoverished Jews recovering from illness. A charitable fund helped provide heating for poor families, and another fund helped new brides. Some of the children were taught religious studies by the community rabbi Magnus Weinberg. He retired in 1935, and was succeeded by Rabbi Dr. Felix Salomon.
Antisemitic incitement against the city’s Jews began when the Nazis rose to power in 1933. In 1934 a Jewish trader was arrested on suspicion of murdering a Christian boy; the Nazi press in Regensburg accused the Jews of murder, but the trader was released when the perpetrators were discovered to be Christian. An economic boycott was also imposed on the Jews. Jews in the marketplace – traders and suppliers – were attacked and their wares were destroyed. In 1934, the Jewish pupils were expelled from the city high schools. After the publication of the Nuremberg Laws, the Jews’ financial situation deteriorated. The Nazis ordered hotel and restaurant owners not to serve Jews.
In response to this antisemitic pressure, many Jews joined the local Zionist movement, and the community began to help traders who had been affected by the economic boycott as well as those who wished to emigrate. This assistance included loans, foreign language courses and professional training courses. The local branch of the Histadrut Hatzionit ran Hebrew language classes. In 1936, with the consent of the Gestapo, a Beit Halutz (pioneer club) was opened in Regensburg to prepare the youth for immigration to Eretz Israel (Mandatory Palestine), but in December 1938 the Gestapo shut it down.
By 1938, 268 Jews had left Regensburg, more than half of them fleeing Germany entirely. As a result of this emigration, many senior citizens were left without support; the community initiated a “Winter Assistance” campaign (Winterhilfe) with the help of the Association of Jewish Women in Bavaria, and in the same year a senior citizens’ home was opened. In 1938, before the November Pogrom ("Kristallnacht"), a Jew was imprisoned on the charge of “racial desecration”, and the glass storefronts of Jewish shops were smashed. Thirteen Jews from Regensburg were deported in the Zbaszyn deportation of October 1938, but in January 1939 an agreement was reached between Poland and Germany, and the deportees from Regensburg were permitted to return home.
During the November Pogrom in 1938, local Nazis destroyed the property in the synagogue and the community center, and burned them down. Jewish homes and stores were destroyed, as well as their belongings and wares. Some 220 Jews, including women and children, were arrested and held at the local police station. Dozens were publicly humiliated and some were sent to the Dachau concentration camp. Members of the Nazi party broke into and looted their apartments. Rabbi Salomon and his wife were forced out of their apartment and ordered to stand outside in their nightwear while their home was being demolished by Nazi thugs. A 66-year-old Jewish trader was beaten to death on arrest.
The Jews being held were released after agreeing to leave Germany. Rabbi Salomon immigrated to England in July 1939, but was killed about a year later in the Blitz.
By 1939, all the traders’ and businessmen’s property had been transferred to Christians as part of the "Aryanization" process. Persecution and imprisonment of Jews continued after the November Pogrom.